FRIDAY, July 3 (HealthDay News) -- Extreme drug-resistant tuberculosis might someday meet its match in two drugs now used to treat Parkinson's disease, suggests a new study.
Researchers, led by a team from the University of California, San Diego, report in the July 3 issue of PLoS Computational Biology that commercially available entacapone and tolcapone have the potential to treat the difficult-to-kill strain of TB.
The discovery was made after a computational analysis that found the chemical structure of the two Parkinson's drugs might work to thwart the TB enzyme InhA, which previous research had determined to be a prime target in treating the disease. A subsequent lab experiment found that the active ingredient in the two drugs inhibited the M. tuberculosis bacterium without being deadly to its host cells.
"We have computational and experimental data to support this [drug] repositioning," principle investigator Philip E. Bourne, a professor of pharmacology at the university's Skaggs School of Pharmacy and Pharmaceutical Sciences, said in a university news release. "Here we have drugs that are known to be safe and with suitable binding properties which can be further optimized to treat a completely different condition."
About 2 million people each year die from extreme drug-resistant tuberculosis, which poses a worldwide threat.
The study's lead author, graduate student Sarah L. Kinnings, said the lab experiment was just a step in the long process of possibly creating a new TB treatment.
"Given the continuing emergence of M. tuberculosis strains that are resistant to all existing, affordable drug treatments, the development of novel, effective and inexpensive drugs is an urgent priority," she said in the news release.
More information
The U.S. Centers for Disease Control and Prevention has more about tuberculosis.
SOURCE: University of California, San Diego, news release, July 2, 2009
Copyright © 2009 ScoutNews, LLC. All rights reserved.
Today's Top News Stories |
• | Ginkgo Won't Prevent Heart Attack, Stroke in Elderly - Nov 24, 2009, 16:00
But the herbal supplement may help ward off peripheral artery disease, researchers say. |
• | Dangerous Toys Still on Store Shelves, Report Finds - Nov 24, 2009, 16:00
Focus on toys that pose choking hazard, are too loud, or contain dangerous chemicals. |
• | Chronic Pain Trips Up Seniors - Nov 24, 2009, 16:00
Discomfort contributes to the falls that plague older adults, study finds. |
• | Clinical Trials Update: Nov. 24, 2009 - Nov 24, 2009, 11:14
- Constipation
- Healthy Volunteers (Ages 18-65)
- Type 2 Diabetes
|
• | Angioplasty Outcomes May Vary Little Between Hospitals - Nov 24, 2009, 16:00
In-hospital death rates didn't differ greatly between high- and low-volume centers, study found. |
