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You are here : AllRefer.com > Health > Diseases & Conditions > Systemic Sclerosis (Scleroderma)

Systemic Sclerosis (Scleroderma)

Provided by A.D.A.M.

Definition

Overview, Causes, & Risk Factors

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Treatment

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Alternate Names : CREST Syndrome, Progressive Systemic Sclerosis, Scleroderma


Definition

Scleroderma is a diffuse connective tissue disease characterized by changes in the skin, blood vessels, skeletal muscles, and internal organs.

Pictures & Images

Raynaud's Phenomenon
Raynaud's Phenomenon

CREST Syndrome
CREST Syndrome

Sclerodactyly
Sclerodactyly

Telangiectasia
Telangiectasia

     See all Pictures & Images
Overview, Causes, & Risk Factors

The cause of scleroderma is unknown. The disease may produce local or systemic symptoms. The course and severity of the disease varies widely in those affected.

Excess collagen deposits in the skin and other organs produce the symptoms. Damage to small blood vessels within the skin and affected organs also occurs. In the skin, ulceration, calcification, and changes in pigmentation may occur.

Systemic features may include fibrosis and degeneration of the heart, lungs, kidneys and gastrointestinal tract.

The disease usually affects people 30 to 50 years old. Women are affected more often than men. Risk factors are occupational exposure to silica dust and polyvinyl chloride.



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Definition
Overview, Causes, & Risk Factors
Symptoms & Signs
Prevention
Diagnosis & Tests
Treatment
Prognosis
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Calling Your Health Care Provider
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Review Date : 8/6/2003
Reviewed By : Megan E. B. Clowse, M.D., M.P.H., Division of Rheumatology, Johns Hopkins Hospital, Baltimore, MD. Review provided by VeriMed Healthcare Network.

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