Acanthosis Nigricans - Close-Up

This photograph demonstrates the hyperpigmented, brownish, velvety plaques of acanthosis nigricans. This skin condition may occur in skin folds such as the axilla (armpit - pictured here), neck, and other areas. In adults, it may be associated with hormonal problems, internal malignancy, obesity, and drugs.

Acanthosis Nigricans on the Hand

This photograph demonstrates brownish, hyperpigmented, velvety plaques overlying the joints of the hands (metacarpal and interphalangeal joints).

Neurofibromatosis, Giant Cafe-Au-Lait Spot

People with neurofibromatosis are at least 5 years old with more than 6 light brown spots (cafe-au-lait spots) larger than 1.5 centimeters. They also have axillary freckles "Crowe's sign" and brown or skin colored nodules (neurofibromas) that are raised above a narrow stock (pedunculated). Networks of nerve-cell tumors that are droopy, soft, doughy masses (plexiform neuromas) are also common. This is a picture of a giant cafe-au-lait spot on a person with neurofibromatosis.

Vitiligo, Drug Induced

The white spots on this person's face have resulted from drug-induced vitiligo. Loss of melanin, the primary skin pigment, occasionally occurs as a result of medications, as is the case with this individual. The typical vitiligo lesion is flat (macular) and depigmented, but maintains the normal skin texture.

Vitiligo on the Face

This is a picture of vitiligo on the face. Complete loss of melanin, the primary skin pigment, occurs for unknown reasons. The resulting lesions are white in comparison to the surrounding skin. Vitiligo may occur in the same areas on both sides of the face (symmetrically) or it may be patchy (asymmetrical). The typical vitiligo lesion is flat (macular) and depigmented, but maintains the normal skin texture. The dark areas around the eyes are this person's normal skin color.

Cutis Marmorata on the Leg

Cutis marmorata is a common phenomena in newborn infants. It consists of alternating areas of dilated and constricted blood vessels, which gives the skin a red and white marbled appearance. It is most obvious when the skin is cool.