Sickle Cell Test
Alternate Names : Hgb S Test, Sickledex
DefinitionThis test indicates the presence or absence of the abnormal hemoglobin that causes sickle cell anemia.
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Why is the Test Performed?
Both sickle cell disease (homozygous for hemoglobin S) and sickle cell trait (heterozygous for Hgb S) can be detected by this test. Sickle cell anemia results from the hereditary presence of abnormal Hgb S in place of Hgb A. When Hgb S becomes deoxygenated (loses oxygen), it tends to form polymers that deform the red blood cells (RBCs) into a sickle shape. Sickled RBCs cannot pass freely through capillaries and cause blockage of small vessels. This can compromise the blood supply to various organs. Hgb S trait is found in 8 to 10% of the black population.
The routine peripheralblood smear does not contain sickled red blood cells unless hypoxemia (inadequate levels of oxygen in the blood) or a precipitating factor (such as a red blood cell poison or drug) is present. In the Sickledex test a deoxygenating agent is added; if 25% or more of the Hgb is Hgb S, the cells will sickle. Another test that can be performed is hemoglobin electrophoresis. This test separates different types of hemoglobin based on electrical charge. Hgb S can be differentiated from Hgb A and other types of Hgb.
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