People with sepsis usually need to be in an intensive care unit (ICU). As soon as sepsis is suspected, "broad spectrum" (able to destroy a wide array of bacteria) intravenous (directly in the vein) antibiotic therapy is begun.

The number of antibiotics may be decreased when blood tests reveal which particular bacteria are causing the infection. The source of the infection should be discovered, if possible. This could mean more testing. Infected intravenous lines or surgical drains should be removed, and any abscesses should be surgically drained.

Oxygen, intravenous fluids, and medications that increase blood pressure may be needed. Dialysis may be necessary if there is kidney failure, and a breathing machine (mechanical ventilation) if there is respiratory failure.

The death rate can be as high as 60% for people with underlying medical problems. The death rate is somewhat lower in those without other medical problems.

• Death
• Disseminated intravascular coagulation
• Impaired blood flow to vital organs (brain, heart, kidneys)
• Septic shock