Secretin Stimulation Test
Alternate Names : Pancreatic Function Test
Definition
This test measures the ability of the pancreas to respond to secretin, a hormone produced by the small intestine when partially digested food has moved into the intestine from the stomach.
Secretin normally stimulates the pancreas to secrete a fluid with a high concentration of bicarbonate. Acting as an antacid, this bicarbonate fluid neutralizes the acidity of the material from the stomach so that enzymes in the small intestine can function properly in the breakdown of food and absorption of nutrients.
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Why is the Test Performed?
The secretin stimulation test is performed to evaluate the function of the pancreas in digestion. People with diseases involving the pancreas such as chronic pancreatitis , cystic fibrosis, or pancreatic cancer may have abnormal pancreatic function.
The bodies of people with cystic fibrosis form mucous plugs that can obstruct the pancreatic ducts that empty into the small intestines. These plugs prevent neutralization of the food acidity, which ultimately reduces the ability to digest and absorb foods.
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