Schilling Test
Alternate Names : Vitamin B12 Absorption Test
DefinitionThe Schilling test is used to determine whether Vitamin B12 is absorbed normally by the body.
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Why is the Test Performed?
The Schilling test is performed to evaluate Vitamin B12 absorption.
Intrinsic factor is produced in the stomach and is required for Vitamin B12 absorption. If intrinsic factor is not made, the body cannot absorb Vitamin B12. Low Vitamin B12 levels can occur from the lack of intrinsic factor because of pernicious anemia, gastrectomy (partial removal of stomach), inadequate absorption due to bowel disease, bacterial overgrowth in the intestine, pancreatic insufficiency or certain medications. The Schilling test is most commonly used to evaluate patients for pernicious anemia.
The test can be falsely positive. Most of the time this is due to inadequate urine collection. Other reasons include kidney disease or problems with the lining of the small intestine.
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