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Rhabdomyolysis
DefinitionRhabdomyolysis is the breakdown of muscle fibers resulting in the release of muscle fiber contents into the circulation. Some of these are toxic to the kidney and frequenty result in kidney damage.
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Overview, Causes, & Risk Factors
Myoglobin is an oxygen-binding protein pigment found in the skeletal muscle. When the skeletal muscle is damaged, the myoglobin is released into the bloodstream. It is filtered out of the bloodstream by the kidneys. Myoglobin may occlude the structures of the kidney, causing damage such as acute tubular necrosis or kidney failure.
Myoglobin breaks down into potentially toxic compounds, which will also cause kidney failure. Necrotic (dead tissue) skeletal muscle may cause massive fluid shifts from the bloodstream into the muscle, reducing the relative fluid volume of the body and leading to shock and reduced blood flow to the kidneys.
The disorder may be caused by any condition that results in damage to skeletal muscle, especially trauma.
Risk factors include the following:
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Jump to another section
• Definition
• Rhabdomyolysis Overview, Causes, & Risk Factors
• Rhabdomyolysis Symptoms & Signs
• Rhabdomyolysis Prevention
• Rhabdomyolysis Diagnosis & Tests
• Rhabdomyolysis Treatment
• Rhabdomyolysis Prognosis
• Rhabdomyolysis Complications
• Calling Your Health Care Provider
• Pictures & Images
Topics that might be of interest to you Diseases & Conditions
• Acute Kidney Failure
• Acute Tubular Necrosis
• Alcoholism
• Arterial Embolism
• Deep Venous Thrombosis
• Hyperkalemia
• Injury - Kidney and Ureter
• Tremor
Tests & Exams
• CPK
• CPK Isoenzymes
• Creatinine - Serum
• Creatinine - Urine
• Hemoglobin
• Myoglobin - Serum
• Myoglobin - Urine
• Potassium Test
• Toxicology Screen
• Urinalysis
• Urinary Casts
Other Topics
• Fatigue
• Heat Emergencies
• Heat Intolerance
• Intravenous
• Joint Pain
• Muscle Aches
• Necrosis
• Seizures
• Shock
• Skin Blushing/Flushing
• Urine - Abnormal Color
• Weakness
• Weight Gain - Unintentional
Review Date : 10/17/2003
Reviewed By : Irfan A. Agha, M.D., Department of Medicine, Renal Division, St. Louis University, St. Louis, MO. Review provided by VeriMed Healthcare Network.
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