• Abdominal pain
• Abnormal urine color (dark, rusty, or brown)
• Back pain
• Blood in the urine
• Emaciated, thin, malnourished appearance
• Enlargement of the veins around a testicle (varicocele)
• Flank pain
• Swelling or enlargement of the abdomen
• Unintentional weight loss of more than 5% of body weight

Other symptoms that can occur with this disease:

• Constipation
• Cold intolerance
• Excessive hair growth in females
• Paleness
• Vision abnormalities

Sometimes both kidneys are involved. The cancer spreads easily, most often to the lungs and other organs. In about one-third of patients, the cancer has already spread (metastasized) at the time of diagnosis.

Pressing with the fingers (palpation) on the abdomen may show a mass or organ enlargement, particularly of the kidney or liver. Men may have a varicocele in the scrotum (a varicocele that is only on the right side is especially suspicious).

Tests include:

• Abdominal CT scan
• Complete blood count (CBC)
• Intravenous pyelogram (IVP)
• Liver function tests
• Renal arteriography
• Serum calcium
• Ultrasound of the abdomen and kidney
• Urine cytology
• Urine test (urinalysis)

The following tests may be performed to see if the cancer has spread:

• Abdominal CT scan
• Abdominal MRI
• Bone scan
• Chest x-ray
• PET scan