Progeria
Alternate Names : Hutchinson-Gilford Syndrome
Definition Progeria is a disease that produces rapid aging starting in childhood.
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Overview, Causes, & Risk Factors
Progeria is a rare condition but has come into public awareness because its symptoms strongly resemble normal human aging as well as the appearance of several affected children in movies on national television.
Lamin A is the name of the gene recently identified as causing some types of progeria. Lamin A codes for a protein that surrounds the nucleus of cells. Further study of lamin A will hopefully answer why mutations in this gene cause such striking premature aging.
Progeria results in rapid aging of children, beginning with growth failure during the first year of life that results in disproportionately small bodies given the size of their heads. The children are thin with baldness, wizened narrow faces, and old-appearing skin.
Children with progeria develop early atherosclerosis. The average lifespan is the early teens. However, some patients can live up to 30 years. The cause of death is usually related to the heart or a stroke as a result of the progressive atherosclerosis.
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