• Enlarged tongue
• Fatigue
• Irregular heart rhythm
• Numbness of hands and feet
• Shortness of breath
• Skin changes
• Swallowing difficulties
• Swelling in the arms and legs
• Weak hand grip
• Weight loss

Additional symptoms that may be associated with this disease:

• Clay-colored stools
• Decreased urine output
• Diarrhea
• Hoarseness or changing voice
• Joint pain
• Other tongue problems
• Weakness

Your doctor may discover that you have an enlarged liver or spleen.

If specific organ damage is suspected, your doctor may order tests to confirm amyloidosis of that organ. For example:

• Abdominal ultrasound may reveal a swollen liver or spleen.
• An abdominal fat pad biopsy, rectal mucosa biopsy, or a bone marrow biopsy can help confirm the diagnosis.
• A heart evaluation, including an ECG,may reveal arrhythmias, abnormal heart sounds, or signs of congestive heart failure. An echocardiogram shows poor motion of the heart wall, due to a stiff heart muscle.
• A carpal tunnel syndrome evaluation may show that hand grips are weak.Nerve conduction velocity shows abnormalities.
• Kidney function tests may show signs of kidney failure or too much protein in the urine ( nephrotic syndrome).
  • BUN level is increased.
  • Serum creatinine is increased.
  • Urinalysis shows protein, casts, or fat bodies.

This disease may also alter the results of the following tests:

• Bence-Jones protein (quantitative)
• Carpal tunnel biopsy
• Gum biopsy
• Immunoelectrophoresis - serum
• Myocardial biopsy
• Nerve biopsy
• Quantitative immunoglobulins
• Tongue biopsy
• Urine protein