Pituitary Cushing's (Cushing's Disease)
DefinitionThis is a condition in which the pituitary gland (an organ of the endocrine system) secretes excess adrenocorticotropic hormone (ACTH).
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Overview, Causes, & Risk Factors
Cushing's disease is a form of Cushing's syndrome, in which excess cortisol (a stress hormone) is secreted. In the case of Cushing's disease, the problem is caused by a tumor or hyperplasia (excess growth) of the pituitary gland. The pituitary gland is located in the base of the skull and regulates the activities of many glands and body processes.
When ACTH is secreted by the pituitary gland, the adrenal glands release cortisol. In Cushing's disease, there is too much ACTH, which leads to an excess release of cortisol. This hormone, normally released during stressful situations, controls the body's use of carbohydrates, fats, and proteins and also plays a role in suppressing the body's response to inflammation.
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