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You are here : AllRefer.com > Health > Diseases & Conditions > Peutz-Jeghers Syndrome

Peutz-Jeghers Syndrome

Provided by A.D.A.M.

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Definition

Peutz-Jeghers syndrome (PJS) is a disorder characterized by intestinal polyps. In addition, pigmented spots develop from infancy through childhood around the lips, gums, mucus membranes, and skin.

The polyps develop most commonly in the small intestine, but also in the colon. There may be a significant risk of these polyps becoming malignant and thus of patients developing cancer. Some studies link PJS and cancers of the gastrointestinal tract, lung, breast, uterus, and ovaries.

There are two types of PJS -- "familial" PJS is inherited, and "sporadic" PJS means there is no known hereditary link.

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Digestive System Organs
Digestive System Organs

 
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Overview, Causes, & Risk Factors

When inherited, Peutz-Jeghers syndrome is transmitted as an autosomal dominant trait. This means that on average, half of the children of someone with familial PJS will inherit PJS.



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Definition
Overview, Causes, & Risk Factors
Symptoms & Signs
Prevention
Diagnosis & Tests
Treatment
Prognosis
Complications
Support Groups
Calling Your Health Care Provider
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Diseases & Conditions

Anemia
Benign Ear Cyst or Tumor
Colorectal Polyps
Intussusception (Children)
Ovarian Cysts

Tests & Exams

Abdominal Film
Biopsy - Polyps
CBC
Stool Guaiac Test
TIBC

Other Topics

Abdominal Pain
Autosomal Dominant
Bleeding
Bloody or Tarry Stools
Chronic
Clubbing of the Fingers or Toes
Genetic Counseling and Prenatal Diagnosis
Nausea and Vomiting

Review Date : 2/22/2002
Reviewed By : ADAM editorial (2/22/2002). Previously reviewed by Michael M. Owens, M.D., Department of Gastroenterology, University of Washington, Seattle, WA. Review provided by VeriMed Healthcare Network (2/9/2002).

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