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Peutz-Jeghers Syndrome
Definition
Peutz-Jeghers syndrome (PJS) is a disorder characterized by intestinal polyps. In addition, pigmented spots develop from infancy through childhood around the lips, gums, mucus membranes, and skin.
The polyps develop most commonly in the small intestine, but also in the colon. There may be a significant risk of these polyps becoming malignant and thus of patients developing cancer. Some studies link PJS and cancers of the gastrointestinal tract, lung, breast, uterus, and ovaries.
There are two types of PJS -- "familial" PJS is inherited, and "sporadic" PJS means there is no known hereditary link.
Pictures & Images
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Overview, Causes, & Risk Factors
When inherited, Peutz-Jeghers syndrome is transmitted as an autosomal dominant trait. This means that on average, half of the children of someone with familial PJS will inherit PJS.
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• Definition
• Overview, Causes, & Risk Factors
• Symptoms & Signs
• Prevention
• Diagnosis & Tests
• Treatment
• Prognosis
• Complications
• Support Groups
• Calling Your Health Care Provider
• Pictures & Images
Topics that might be of interest to you Diseases & Conditions
• Anemia
• Benign Ear Cyst or Tumor
• Colorectal Polyps
• Intussusception (Children)
• Ovarian Cysts
Tests & Exams
• Abdominal Film
• Biopsy - Polyps
• CBC
• Stool Guaiac Test
• TIBC
Other Topics
• Abdominal Pain
• Autosomal Dominant
• Bleeding
• Bloody or Tarry Stools
• Chronic
• Clubbing of the Fingers or Toes
• Genetic Counseling and Prenatal Diagnosis
• Nausea and Vomiting
Review Date : 2/22/2002
Reviewed By : ADAM editorial (2/22/2002). Previously reviewed by Michael M. Owens, M.D., Department of Gastroenterology, University of Washington, Seattle, WA. Review provided by VeriMed Healthcare Network (2/9/2002).
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