Pemphigus vulgaris
Definition
Pemphigus vulgaris is an autoimmune disorder that involves blistering of the skin and mucous membrane.
Overview, Causes, & Risk Factors
Pemphigus is an autoimmune disorder. The immune system produces antibodies against specific proteins in the skin and mucous membrane. These antibodies create a reaction that cause skin cells to separate. The exact cause is unknown. Sometimes pemphigus is caused by certain medications, although this is rare. Medications that may cause this condition include:
- Blood pressure medications called ACE inhibitors
- Chelating agents such as penicillamine, which remove certain materials from the blood
Pemphigus is uncommon. It occurs almost exclusively in middle-aged or older people.
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