Nikolsky's Sign
Definition A condition in which the superficial layers of skin slip free from the lower layers with a slight rubbing pressure.
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Overview & Considerations
A positive Nikolsky's sign is present in the scalded skin syndrome (caused by staphylococcal infection) and in a slightly different form in toxic epidermal necrolysis (a severe drug reaction). It may also be seen in pemphigus vulgaris (a disease which causes blisters to form on the skin).
In each of these diseases, the skin is loosened and when rubbed, slips free just as the skin on a blanched tomato or peach would do. The area beneath is pink and moist and may be very tender.
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