Neurofibromatosis-1 (NF1, Von Recklinghausen neurofibromatosis)

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Neurofibromatosis-1

Alternate Names : NF1, Von Recklinghausen neurofibromatosis

Definition

Neurofibromatosis-1 is an inherited disorder in which nerve tissue tumors (neurofibromas) form in the skin, bottom layer of skin (subcutaneous tissue), and nerves from the brain (cranial nerves) and spinal cord (spinal root nerves).

Overview, Causes, & Risk Factors

NF1 is an inherited disease. If either parent has NF1, each of their children has a 50% chance of having the disease.

NF1 also appears in families with no previous history of the condition, as a result of a new gene change (mutation) in the sperm or egg. NF1 is caused by abnormalities in a gene for a protein called neurofibromin.

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Neurofibroma

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Neurofibromatosis-1 : Definition
Neurofibromatosis-1 : Overview, Causes, & Risk Factors
Neurofibromatosis-1 : Symptoms & Signs
Neurofibromatosis-1 : Diagnosis & Tests
Neurofibromatosis-1 : Treatment
Neurofibromatosis-1 : Support Groups
Neurofibromatosis-1 : Prognosis (Expectations)
Neurofibromatosis-1 : Complications
Neurofibromatosis-1 : Calling Your Health Care Provider
Neurofibromatosis-1 : Prevention
Neurofibromatosis-1 : References
Neurofibromatosis-1 : Pictures & Images
Neurofibroma

Review Date : 8/7/2008
Reviewed By : Diana Chambers, MD, EdD, Certified Genetics Counselor (ABMG), Charter Member of the ABGC, Univresity of Tennessee, Memphis, TN. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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