Fever, chills, fatigue, or weight loss may be the only symptoms at first. However, symptoms may be in almost any part of the body.

Skin:

• Abnormal skin tissue (lesions)
  • Papules (small, solid, and raised lesions)
  • Red or purple colored
  • Located on the legs, hands, or other parts of the body
• Fingers that change color (blue fingers or toes)
• Tissue death due to lack of oxygen
  • Pain or tenderness in the area
  • Skin redness
  • Sores (ulcers) that do not heal

Muscles and joints:

• Joint pain
• Leg pain
• Muscle contractions
• Wasting away of muscles

Brain and nervous system:

• Pain, numbness, tingling in an arm, leg, or other body area
• Weakness of an arm, leg, or other body area
• Pupils that are different sizes
• Eyelid drooping
• Swallowing difficulty
• Speech impairment
• Movement difficulty

Other symptoms include:

• Abdominal pain
• Blood in the urine or stools
• Painful menstruation
• Hoarseness or changing voice
• Symptoms related to damage of the arteries that supply the heart (coronary arteries)

The doctor will perform a physical exam. A nervous system (neurological) examination may show signs of nerve damage.

Tests that may be done include:

• Biopsy of the muscle, organ, tissue, or nerve biopsy
• Chest x-ray
• Sedimentation rate
• Urinalysis
• Hepatitis blood test
• Blood test for antibodies against neutrophils (ANCA antibodies)