Multiple lentigines syndrome
Alternate Names : Leopard syndrome
Definition
Multiple lentigines syndrome is an inherited disorder identified by an increased number of lentigines (freckle-like spots).
Overview, Causes, & Risk Factors
Multiple lentigines syndrome is inherited as an autosomal dominant trait. People with this condition have large numbers of lentigines. Lentigines are skin markings that are somewhat darker than true freckles. They are present from birth. They are located mostly on the trunk and neck. Affected people also have wide-set eyes (hypertelorism), prominent ears, nerve deafness (partial), and cafe-au-lait spots (light brown birthmarks).
In contrast, having scattered lentigines is normal and does not indicate a problem. Additional symptoms include mild pulmonic stenosis and changes in the ECG (electrocardiogram). People with this condition may have abnormal genitalia (cryptorchidism), hypogonadism, or delayed puberty.
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