Multiple endocrine neoplasia (MEN) II
Alternate Names : Sipple's syndrome
Definition
Multiple endocrine neoplasia II (MEN II) is an uncommon condition passed down through families (inherited), in which the thyroid, adrenal, and parathyroid glands are overactive. See also: MEN I
Overview, Causes, & Risk Factors
The cause of MEN II is a defect in a gene called RET. This defect causes many tumors to appear in the same person, but not necessarily at the same time. The adrenal tumor is called a pheochromocytoma, and the thyroid tumor is a medullary carcinoma of the thyroid. The disorder may occur at any age, and affects men and women equally. The main risk factor is a family history of MEN II.
There are two similar subtypes of MEN II -- MEN IIa and IIb. MEN IIb is less common.
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