Multiple endocrine neoplasia (MEN) I (Wermer syndrome, MEN I)

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Multiple endocrine neoplasia (MEN) I

Alternate Names : Wermer syndrome, MEN I

Definition

Multiple endocrine neoplasia (MEN) I is an inherited disorder in which one or more of the endocrine glands are overactive or form a tumor. Endocrine glands most commonly involved include:

Adrenals
Pancreas
Parathyroid
Pituitary
Thyroid

Overview, Causes, & Risk Factors

MEN I is caused by a defect in a gene called RET. The condition causes tumors of various glands to appear in the same person, but not necessarily at the same time. The disorder may occur at any age, and it affects men and women equally.

Risk factors for MEN I include:

Family history of this disorder
Pituitary tumor
Zollinger-Ellison syndrome

Pictures & Images

Endocrine glands

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Multiple endocrine neoplasia (MEN) I : Definition
Multiple endocrine neoplasia (MEN) I : Overview, Causes, & Risk Factors
Multiple endocrine neoplasia (MEN) I : Symptoms & Signs
Multiple endocrine neoplasia (MEN) I : Diagnosis & Tests
Multiple endocrine neoplasia (MEN) I : Treatment
Multiple endocrine neoplasia (MEN) I : Prognosis (Expectations)
Multiple endocrine neoplasia (MEN) I : Complications
Multiple endocrine neoplasia (MEN) I : Calling Your Health Care Provider
Multiple endocrine neoplasia (MEN) I : Prevention
Multiple endocrine neoplasia (MEN) I : References
Multiple endocrine neoplasia (MEN) I : Pictures & Images
Endocrine glands

Review Date : 9/4/2008
Reviewed By : Sean O. Stitham, MD, private practice in Internal Medicine, Seattle, Washington; and James R. Mason, MD, Oncologist, Director, Blood and Marrow Transplantation Program and Stem Cell Processing Lab, Scripps Clinic, Torrey Pines, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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