Mouth sores generally last 10 to 14 days, even if you don't do anything. They sometimes last up to 6 weeks. The following steps can make you feel better:

• Gargle with cool water or eat popsicles. This is particularly helpful if you have a mouth burn.
• Avoid hot beverages and foods, spicy and salty foods, and citrus.
• Take pain relievers like acetaminophen.

For canker sores:

• Rinse with salt water.
• Apply a thin paste of baking soda and water.
• Mix 1 part hydrogen peroxide with 1 part water and apply this mixture to the lesions using a cotton swab.
• For more severe cases, treatments include fluocinonide gel (Lidex), the anti-inflammatory amlexanox paste (Aphthasol), or chlorhexidine gluconate (Periden) mouthwash.

Nonprescription preparations, like Orabase, can protect a sore inside the lip and on the gums. Blistex or Campho-Phenique may provide some relief of canker sores and fever blisters, especially if applied when the sore initially appears.

Additional steps that may help cold sores or fever blisters:

• Apply ice to the lesion.
• Take L-lysine tablets.

Antiviral medications for herpes lesions of the mouth may be recommended by your doctor. Some experts feel that they shorten the time that the blisters are present, while others claim that these drugs make no difference.

Call your doctor if:

• The sore begins soon after you start a new medication
• You have large white patches on the roof of your mouth or your tongue (this may be thrush or another type of lesion)
• Your mouth sore lasts longer than 2 weeks
• You are immunocompromised (for example, from HIV or cancer)
• You have other symptoms like fever, skin rash, drooling, or difficulty swallowing

Your doctor will perform a physical examination, focusing on your mouth and tongue. Medical history questions may include the following:

• Are the sores on your lips, gums, tongue, lining of your cheeks, or elsewhere?
• Are the sores open ulcers?
• Are there large, white patches on the roof of the mouth or on your tongue?
• How long have you had the mouth sores? More than 2 weeks?
• Have you ever had sores of this type before?
• What medications do you take?
• Do you have other symptoms like fever, sore throat, or breath odor?

Treatment may depend on the underlying cause of the mouth sore.

A topical anesthetic (applied to a localized area of the skin) such as lidocaine or xylocaine may be used to relieve pain (but should be avoided in children).

An antifungal medication may be prescribed for oral thrush (a yeast infection).

An antiviral medication may be prescribed for herpes lesions (although, some feel that this does not shorten the length of time that the lesions are present)

Anti-inflammatory medications may be prescribed for severe or persistent canker sores.