The goals of treatment are to:

• Treat the cause, if possible
• Provide supportive care to maximize independence
• Control symptoms (this may include controlling blood sugar levels for diabetics, nutritional supplementation, or medical treatment of conditions)

To improve independence, treatments may include:

• Occupational therapy
• Orthopedic help (for example, appliances such as wheelchairs, braces, and splints)
• Physical therapy (for example, exercises and retraining to increase muscle strength)
• Vocational therapy

Safety is an important consideration for people with sensation or movement difficulties. Lack of muscle control and decreased sensation may increase the risk of falls or injuries. Safety measures for people with movement difficulty may include:

• Adequate lighting (including leaving lights on at night)
• Railings
• Removing obstacles (such as loose rugs that may slip on the floor)
• Testing water temperature before bathing
• Wearing protective shoes (no open toes or high heels)

Check shoes often for grit or rough spots that may injure the feet.

People with decreased sensation should check their feet (or other affected area) often for bruises, open skin areas, or other injuries that may go unnoticed. These injuries may become severely infected because the pain nerves of the area are not signalling the injury.

People with mononeuropathy multiplex are prone to new nerve injuries at pressure points such as knees and elbows. They should avoid putting pressure on these areas, for example by not leaning on the elbows, crossing the knees, or holding similar positions.

Over-the-counter analgesics or prescription pain medications may be needed to control pain (neuralgia). Other medications, including anticonvulsants (gabapentin, phenytoin, carbamazepine) or tricyclic antidepressants, may be used to reduce the stabbing pains that some people experience. Whenever possible, avoid or minimize the use of medications to reduce the risk of side effects.

Positioning (the use of frames to keep bedclothes off of a tender body part) and other measures may help control pain. Autonomic symptoms can be difficult to treat or respond poorly to treatment.

If the cause can be found and successfully treated, and if damage is limited, a full recovery is possible. The amount of disability can range from no disability, to partial or complete loss of movement, function, or sensation.

Nerve pain may be quite uncomfortable and can last for a long time. If this occurs, see a pain specialist to ensure that all pain treatment options are available to you.

• Decreased self-esteem
• Deformity, loss of tissue mass
• Disturbances of organ functions
• Recurrent or unnoticed injury to any part of the body
• Relationship problems due to impotence

Call your health care provider if you notice signs of mononeuritis multiplex.