Minimal Change Disease
Alternate Names : Idiopathic Nephrotic Syndrome of Childhood, Lipoid Nephrosis, Minimal Change Nephrotic Syndrome, Nil Disease
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Treatment
Swelling may be treated with diuretics, blood pressure control, and ACE inhibitor medicines. You may receive instructions on how much salt to allow in your diet.
Corticosteroids can cure minimal change disease in a vast majority of children. Some patients may require maintenance on steroids to sustain the remission.
A minority of children may relapse after they stop taking steroids. If that happens, they usually respond well to a repeat course of the steroids. Adults do not respond to steroids quite as well as children, but a majority still do find steroids effective. The frequency of relapses and steroid dependence may be greater in adults.
Frequent relapsers (more than 3 relapses) may need cytotoxic therapy. In most cases, this involves a course of cyclophosphamide. Other medicines that have been used include cyclosporine and chlorambucil.
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