Methylene Blue Test
Definition
The methylene blue test is a test to determine the type of methemoglobinemia an affected person has, based on the responsiveness of blood methemoglobin to the administration of methylene blue (a dark green powder that can turn methemoglobin back into normal hemoglobin).
Why is the Test Performed?
Methemoglobinemia has several causes, many of which are genetic. This test assists in distinguishing between methemoglobinemia caused by a deficiency of NADH cytochrome b5 reductase and certain types of hereditary methemoglobinemia caused by hemoglobin M disease.
Most methemoglobinemia quickly responds to IV administration of methylene blue, and can be controlled by daily doses of oral methylene blue and ascorbic acid. However, some types of hereditary methemoglobinemia do not respond to methylene blue. This test allows distinction between the two and helps your health care provider develop a plan of care.
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