McCune-Albright syndrome (Polyostotic fibrous dysplasia)

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McCune-Albright syndrome

Alternate Names : Polyostotic fibrous dysplasia

Definition

McCune-Albright syndrome is a genetic disease that affects the bones and color (pigmentation) of the skin.

Overview, Causes, & Risk Factors

McCune-Albright syndrome is caused by mutations in the GNAS1 gene. The abnormal gene is present in a fraction, but not all, of the patient's cells (mosaicism).

This disease is not inherited. It is caused by a new change (mutation) to the DNA that occurs in the womb while the baby is developing. This mutation is not passed on to any of the person's children.

Pictures & Images

Anterior skeletal anatomy

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McCune-Albright syndrome : Definition
McCune-Albright syndrome : Overview, Causes, & Risk Factors
McCune-Albright syndrome : Symptoms & Signs
McCune-Albright syndrome : Diagnosis & Tests
McCune-Albright syndrome : Treatment
McCune-Albright syndrome : Prognosis (Expectations)
McCune-Albright syndrome : Complications
McCune-Albright syndrome : Calling Your Health Care Provider
McCune-Albright syndrome : References
McCune-Albright syndrome : Pictures & Images
Anterior skeletal anatomy

Review Date : 8/7/2008
Reviewed By : Diana Chambers, MS, EdD, Certified Genetics Counselor (ABMG), Charter Member of the ABGC, University of Tennessee, Memphis, TN. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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