Malaise is a generalized feeling of discomfort, illness, or lack of well-being.

Malaise is a symptom that can occur with almost any significant health condition. It may start slowly or quickly, depending on the type of disease.

Fatigue occurs with malaise in many common diseases. Mailaise can be accompanied by a feeling of not having enough energy to accomplish usual activities.

The following lists give examples of the diseases, conditions, and medications that can cause malaise.

SHORT-TERM (ACUTE) INFECTIOUS DISEASE

• Acute bronchitis or pneumonia
• Acute viral syndrome
• Infectious mononucleosis (EBV)
• Influenza
• Lyme disease

LONG-TERM (CHRONIC) INFECTIOUS DISEASE

• AIDS
• Chronic active hepatitis
• Disease caused by parasites
• Tuberculosis

HEART AND LUNG (CARDIOPULMONARY) DISEASE

• Congestive heart failure
• COPD

ORGAN FAILURE

• Acute or chronic kidney disease
• Acute or chronic liver disease

CONNECTIVE TISSUE DISEASE

• Rheumatoid arthritis
• Sarcoidosis
• Systemic lupus erythematosus

ENDOCRINE or METABOLIC DISEASE

• Adrenal gland dysfunction
• Diabetes
• Pituitary gland dysfunction (rare)
• Thyroid disease

CANCER

• Leukemia
• Lymphoma (cancer that starts in the lymph system)
• Solid tumor cancers, such as colon cancer

BLOOD DISORDERS

• Severe anemia

PSYCHIATRIC

• Depression
• Dysthymia

MEDICATIONS

• Anticonvulsant (antiseizure) medications
• Antihistamines
• Beta blockers (medications used to treat heart disease or high blood pressure)
• Psychiatric medications
• Treatments involving several medications