Treatment focuses on the cause of the problem. Avoiding medications that lead to this condition may relieve the symptoms quickly.

Limiting salt and fluid in the diet can improve swelling and high blood pressure. Limiting protein in the diet can help control the buildup of waste products in the blood (azotemia) that can lead to symptoms of acute kidney failure.

If dialysis is necessary, it usually is required for only a short time.

Corticosteroids or anti-inflammatory medications can help in some cases.

Most often, interstitial nephritis is a short-term disorder. In rare cases, it can cause permanent damage, including chronic kidney failure.

Metabolic acidosis can occur because the kidneys aren't able to remove enough acid. The disorder can lead to acute or chronic kidney failure or end-stage kidney disease.

Call your health care provider if you have symptoms of interstitial nephritis.

If you have interstitial nephritis, call your health care provider if you get new symptoms, especially if you are less alert or have a decrease in urine output.