The underlying disease must be treated. Treatment of the cornea with corticosteroid drops may minimize scarring and help preserve the clarity of the cornea.

Once the clear covering of the cornea is gone, a corneal transplantation is required.

If interstitial keratitis is diagnosed early and treated effectively, the corneal clarity and thus good vision will be preserved.

A corneal transplantation is not as successful for interstitial keratitis as it is for most other corneal diseases. The presence of blood vessels in the diseased cornea brings white blood cells to the newly transplanted cornea and increases the risk of rejection.

All patients with interstitial keratitis will be closely followed by an ophthalmologist and a medical specialist with expertise in the underlying disease. Any worsening pain, increasing redness, or decreasing vision should be evaluated immediately. This is particularly crucial for patients with corneal transplants.