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Hypogonadotropic Hypogonadism
Alternate Names : Gonadotropin Deficiency, Kallmann Syndrome, Secondary Hypogonadism
Definition Absent or decreased gonadal function (the male testis or the female ovary) resulting from the absence of the gonadal stimulating pituitary hormones FSH (follicle stimulating hormone) and LH (luteinizing hormone).
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Overview, Causes, & Risk Factors
One area of the brain, the hypothalmus, secretes hormones (GnRH) to stimulate the pituitary gland. In response, the pituitary gland (located near the brain) secretes other hormones (FSH and LH).
These, in turn, stimulate the ovaries (female) and testes (male) to secrete hormones that are responsible for normal sexual development in puberty. Any disruption in this cascade causes a deficiency of the sex hormones and halts normal pubertal sexual maturation.
Failure of the hypothalamus is most commonly a result of Kallmann syndrome. Kallmann syndrome is an inherited disorder that usually includes a disorder of the sense of smell. Failure of the pituitary may result from empty sella syndrome, pituitary tumors (craniopharyngioma), head injuries, or other causes.
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• Definition
• Overview, Causes, & Risk Factors
• Symptoms & Signs
• Prevention
• Diagnosis & Tests
• Treatment
• Prognosis
• Complications
• Calling Your Health Care Provider
• Pictures & Images
Topics that might be of interest to you Diseases & Conditions
• Craniopharyngioma
• Empty Sella Syndrome
• Infertility
• Pituitary Tumor
Tests & Exams
• FSH
• LH Blood Test
• MRI of the Head
• Testosterone
Other Topics
• Head Injury
• Testes
Review Date : 3/1/2002
Reviewed By : Chayim Y. Newmark M.D., Department of Pediatrics, St. Louis Children's Hospital, St. Louis, MO. Review provided by VeriMed Healtchare Network.
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