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Hyperimmunoglobulin E Syndrome
Alternate Names : Hyper IgE Syndrome, Job Syndrome
DefinitionHyperimmunoglobulin E syndrome is a suspected genetic defect that results in the production of high levels of the antibody immunoglobulin (IgE), causing serious skin and lung infections as well as eczema.
Overview, Causes, & Risk Factors
Hyperimmunoglobulin E syndrome is also know as Job syndrome, after the biblical character Job whose faithfulness was tested by a lifelong affliction of draining skin sores and pustules. People afflicted have chronic severe skin infections and abscess formation. The sinuses and airways (including lungs) are also frequently infected. Other sites of infection include bone and visceral abscesses. The most commonly involved bacteria is Staphylococcus aureus. Other common organisms are Streptococcus pneumoniae (bacterium), Hemophilus influenzae (bacterium), Candida albicans (yeast), and the herpes virus (virus).
Hyper IgE syndrome is in most cases inherited in a dominant fashion, meaning that it can run in families with high frequency.
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• Definition
• Overview, Causes, & Risk Factors
• Symptoms & Signs
• Prevention
• Diagnosis & Tests
• Treatment
• Prognosis
• Complications
• Calling Your Health Care Provider
Topics that might be of interest to you Diseases & Conditions
• Abscess
• Allergic Rhinitis
• Asthma
• Eczema (Atopic Dermatitis)
• Osteomyelitis
• Sepsis
• Sinusitis
Tests & Exams
• Bone X-Ray
• CBC
• Chest X-Ray
• Eosinophil Count - Absolute
• Pulmonary Angiography
• Sinuses X-Ray
Other Topics
• Chronic
• Nasal Discharge
• Pustules
• Subcutaneous
Review Date : 10/30/2003
Reviewed By : Donald Accetta, MD, MPH. President, Allergy & Asthma Care, PC, Taunton, MA. Review provided by VeriMed Healthcare Network.
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