Hormone Replacement Therapy (HRT)
Alternate Names : ERT (Estrogen Replacement Therapy), HRT
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Blood clots/thromboembolic disease
The increased risk of blood clots from taking estrogen has been recognized for years. Generally, this risk has been associated with the use of oral contraceptives that contain high doses of estrogen. It is further increased for women who smoke cigarettes.
The WHI study confirmed an increase in the number of blood clots in women taking estrogen/progestin. For every 10,000 women taking HRT, 34 will develop clots in their lungs or legs, while 16 in 10,000 not taking HRT will develop blood clots.
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