Most cases of histoplasmosis clear up on their own. No treatment is needed beyond bedrest and medication to control fever.

If you are sick for more than one month or are having breathing problems, your doctor may prescribe medication. Drugs used to treat this condition include itraconazole and amphotericin B.

When histoplasmosis infection is severe and progressive, the illness may last for one to six months. Even then, it is rarely fatal. It can be a serious illness in people with weak immune systems, such as those who have had bone marrow or solid organ transplants, those who have AIDS, or those who take medications to suppress their immune system.

Histoplasmosis can spread to other organs through the bloodstream (dissemination). This is usually seen in infants, young children, and immunosuppressed patients.

Acute histoplasmosis can get progressively worse or can become chronic histoplasmosis (doesn't go away).

Call your health care provider if you have symptoms of histoplasmosis, especially if you have an immune disorder, have been recently exposed to bird or bat droppings, or if you are being treated for histoplasmosis and new symptoms develop.