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Factor VII Deficiency
Alternate Names : Extrinsic Factor Deficiency
Definition Factor VII deficiency is an inherited disorder that causes abnormal blood clotting (coagulation), resulting from a deficiency of the plasma protein factor VII.
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Overview, Causes, & Risk Factors
This disorder is caused by an inherited deficiency of factor VII, an important clotting protein. Normal blood coagulation is a complex process involving as many as 20 different plasma proteins, which are known as blood coagulation factors. A series of complex chemical reactions using these factors takes place very rapidly to form an insoluble protein called fibrin that stops bleeding.
When certain coagulation factors are deficient or missing, the chain reaction does not take place normally. In this disorder, bleeding can vary from mild to severe within the same person over time. A history of bleeding may occur in infancy or childhood. Gastrointestinal and central nervous system bleeding can occur.
The risk factor is a family history of bleeding. The incidence is 1 in 500,000.
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• Definition
• Factor VII Deficiency Overview, Causes, & Risk Factors
• Factor VII Deficiency Symptoms & Signs
• Factor VII Deficiency Prevention
• Factor VII Deficiency Diagnosis & Tests
• Factor VII Deficiency Treatment
• Factor VII Deficiency Prognosis
• Factor VII Deficiency Complications
• Factor VII Deficiency Support Groups
• Calling Your Health Care Provider
• Pictures & Images
Topics that might be of interest to you Diseases & Conditions
• Stroke
Tests & Exams
• Factor VII Assay
• Partial Thromboplastin Time (PTT)
• Prothrombin Time (PT)
Other Topics
• Bleeding
• Bleeding Into the Skin
• Central Nervous System
• Hemophilia - Resources
• Menstrual Periods - Heavy, Prolonged, or Irregular
• Nosebleed
Review Date : 8/18/2003
Reviewed By : Corey Cutler, M.D., M.P.H., F.R.C.P.C, Department of Medical Oncology, Dana-Farber Cancer Institute; Instructor in Medicine, Harvard University, Boston, MA. Review provided by VeriMed Healthcare Network.
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