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Factor II Deficiency
Alternate Names : Hypoprothrombinemia, Prothrombin Deficiency
Definition Factor II deficiency is a disorder of blood clotting (coagulation) resulting from a deficiency of prothrombin.
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Overview, Causes, & Risk Factors
Normal blood coagulation is a complex process involving as many as 20 different plasma proteins, which are known as blood coagulation factors. A series of complex chemical reactions using these factors takes place very rapidly to form an insoluble protein called fibrin that stops bleeding. When certain coagulation factors are deficient or missing, the chain reaction does not take place normally. In this disorder, bleeding ranges from mild to severe.
A congenital factor II deficiency is a very rare inherited disorder that results in deficient blood clotting. It is inherited as an autosomal recessive trait (both parents are carriers). A family history of a bleeding disorder is a risk factor.
Acquired factor II deficiency is common and results from vitamin K deficiency, severe liver disease, and therapeutic use of anticoagulant drugs. Risk factors for vitamin K deficiency are prolonged use of antibiotics, bile duct obstruction, and intestinal malabsorption (inadequate absorption of nutrients from the intestinal tract) disorders. Some newborns are born with vitamin K deficiency.
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• Definition
• Factor II Deficiency Overview, Causes, & Risk Factors
• Factor II Deficiency Symptoms & Signs
• Factor II Deficiency Prevention
• Factor II Deficiency Diagnosis & Tests
• Factor II Deficiency Treatment
• Factor II Deficiency Prognosis
• Factor II Deficiency Complications
• Factor II Deficiency Support Groups
• Calling Your Health Care Provider
• Pictures & Images
Topics that might be of interest to you Diseases & Conditions
• Biliary Obstruction
• Bleeding Disorders
• Liver Disease
• Malabsorption
Tests & Exams
• Factor II Assay
• Partial Thromboplastin Time (PTT)
• Prothrombin Time (PT)
Other Topics
• Bleeding
• Bleeding Into the Skin
• Hemophilia - Resources
• Nosebleed Injury
• Vitamin K
Review Date : 8/18/2003
Reviewed By : Corey Cutler, M.D., M.P.H., F.R.C.P.C, Department of Medical Oncology, Dana-Farber Cancer Institute; Instructor in Medicine, Harvard University, Boston, MA. Review provided by VeriMed Healthcare Network.
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