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Dubin-Johnson Syndrome
Definition Dubin-Johnson syndrome is an inherited disorder characterized by mild jaundice throughout life.
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Overview, Causes, & Risk Factors
Dubin-Johnson syndrome is a very rare autosomal recessive disorder, which means that in order to inherit the condition, a child must get a copy of the defective gene from both parents.
The transport of bilirubin from the liver is dysfunctional in people with this condition. Bilirubrin is a product of the liver's metabolism of worn-out red blood cells and is normally sent into the digestive system. When bilirubin is not properly processed, it builds up in the bloodstream and causes the skin and the whites of the eyes take on a yellow tinge. Severely high levels can damage the brain and other organs.
People with Dubin-Johnson syndrome have life-long low-grade jaundice that may be aggravated by alcohol, pregnancy, oral contraceptive use, infection, and other environmental factors that affect the liver.
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• Definition
• Overview, Causes, & Risk Factors
• Symptoms & Signs
• Prevention
• Diagnosis & Tests
• Treatment
• Prognosis
• Complications
• Calling Your Health Care Provider
• Pictures & Images
Topics that might be of interest to you Tests & Exams
• Bilirubin
• Liver Biopsy
Other Topics
• Abdominal Pain
• Jaundice - Yellow Skin
Review Date : 1/13/2003
Reviewed By : Andrew J. Muir, M.D., M.H.S., Division of Gastroenterology, Duke University Medical Center, Durham, NC. Review provided by VeriMed Healthcare Network.
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