Drug-Induced Hypothyroidism
DefinitionDrug-induced hypothyroidism involves decreased activity of the thyroid gland caused by an adverse reaction to a medication.
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Overview, Causes, & Risk Factors
Hypothyroidism (underactivity of the thyroid gland) can cause a variety of symptoms that affect the entire body. The body's normal rate of functioning slows, causing mental and physical sluggishness. Symptoms vary from mild to severe.
Drug-induced hypothyroidism may be caused by treatment with lithium or iodides in susceptible people. Drugs used for hyperthyroidism (overactive thyroid) such as PTU and methimazole may cause unintentional hypothyroidism. Unusual causes of drug-induced hypothyroidism include nitroprusside, perchlorate, and sulfonylureas.
The most severe form of hypothyroidism is called myxedema coma, which is a medical emergency. Severe hypothyroidism, however, is seldom drug-related.
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