Drug-induced cholestasis (Cholestasis

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Drug-induced cholestasis

Alternate Names : Cholestasis - drug-induced

Definition

Drug-induced cholestasis is a blockage in the flow of bile from the liver that occurs with medication use.

Overview, Causes, & Risk Factors

Bile is produced in the liver, moved to the gallbladder, and released into the gut through the biliary tract. It helps the body digest fats.

Certain drugs can slow or stop the flow of bile from the liver to the gallbladder and gut, which may damage the liver.

Many drugs can cause cholestasis, including:

Ampicillin and other penicillin-based antibiotics
Anabolic steroids
Chlorpromazine
Cimetidine
Erythromycin
Gold salts
Imipramine
Nitrofurantoin
Oral contraceptives
Prochlorperazine
Sulindac
Tobutamide

Other medications can also cause cholestasis in some people.

Pictures & Images

Bile pathway

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Drug-induced cholestasis : Definition
Drug-induced cholestasis : Overview, Causes, & Risk Factors
Drug-induced cholestasis : Symptoms & Signs
Drug-induced cholestasis : Diagnosis & Tests
Drug-induced cholestasis : Treatment
Drug-induced cholestasis : Prognosis (Expectations)
Drug-induced cholestasis : Complications
Drug-induced cholestasis : Calling Your Health Care Provider
Drug-induced cholestasis : Pictures & Images
Bile pathway

Review Date : 8/22/2008
Reviewed By : Christian Stone, MD, Division of Gastroenterology, Washington University in St. Louis School of Medicine, St. Louis, MO. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

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