Diabetes Insipidus
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Diabetes Insipidus Treatment
The cause of the underlying condition should be treated when possible.
Central diabetes insipidus may be controlled with vasopressin (desmopressin, DDAVP). Vasopressin is administered as either a nasal spray or tablets.
Vasopressin is ineffective for patients with nephrogenic DI. In most cases, if nephrogenic DI is caused by medication (for example, lithium), stopping the medication leads to recovery of normal kidney function.
Hereditary nephrogenic DI is treated with fluid intake to match urine output and drugs that lower urine output. Drugs used to treat nephrogenic DI include the anti-inflammatory medication indomethacin and the diuretics hydrochlorothiazide (HCTZ) and amiloride.
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