Coombs' Test - Direct
DefinitionThe direct Coombs' test measures the presence of antibodies on the surface of red blood cells.
Why is the Test Performed?
The direct Coombs' test is used to detect autoantibodies against your own red blood cells (RBCs). Many diseases and drugs (e.g., quinidine, methyldopa, and procainamide) can lead to production of these antibodies.
These antibodies sometimes destroy red blood cells and cause anemia. This test is sometimes performed to diagnose the cause of anemia, jaundice, or abnormalities in the appearance of red blood cells under the microscope.
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