Congenital afibrinogenemia
Definition
Congenital afibrinogenemia is a rare, inherited blood disorder in which the blood does not clot normally. It occurs when there is a lack (deficiency) of a protein called fibrinogen, which is needed for the blood to clot.
Overview, Causes, & Risk Factors
This rare disease is caused by an abnormal gene that must be passed down from both parents. It causes a severe lack of fibrinogen. (Dysfibrinogenemia, in which there is a defect in fibrinogen function, is a different condition.) Congenital afibrinogenemia can occur in males or females. The main risk factor is a family history of bleeding disorders.
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