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Hemoglobin C Disease
Alternate Names : Clinical Hemoglobin C
DefinitionHemoglobin C disease is a genetic blood disorder. It results in a chronic anemia in which the red blood cells are broken down prematurely.
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Overview, Causes, & Risk Factors
Hemoglobin C is a hemoglobinopathy, caused by an inherited abnormality of the beta globin gene. This disorder is inherited as an autosomal recessive trait. Hemoglobin C produces a mild type of anemia that occurs because the red blood cells containing abnormal hemoglobin are broken down prematurely.
Normal hemoglobin, known as hemoglobin A, is also present. The spleen may be enlarged, and there may be jaundice, a yellow color of the skin. Gallstones may develop and require treatment in adulthood.
The disease occurs predominantly in the black race. A family history of hemoglobin C is a risk factor. In combination with sickle hemoglobin, it results in Hemoglobin SC disease, which is characterized by hemolysis and painful crises. It is usually milder than sickle cell disease.
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• Definition
• Hemoglobin C Disease Overview, Causes, & Risk Factors
• Hemoglobin C Disease Symptoms & Signs
• Hemoglobin C Disease Prevention
• Hemoglobin C Disease Diagnosis & Tests
• Hemoglobin C Disease Treatment
• Hemoglobin C Disease Prognosis
• Hemoglobin C Disease Complications
• Calling Your Health Care Provider
• Pictures & Images
Topics that might be of interest to you Diseases & Conditions
• Anemia
• Cholelithiasis
• Gallbladder Disease
• Hemoglobinopathy
Tests & Exams
• Blood Smear
• Hemoglobin Electrophoresis
• Serum Hemoglobin
Other Topics
• Folic Acid (Folate)
• Jaundice - Yellow Skin
• Splenomegaly
Review Date : 8/18/2003
Reviewed By : Corey Cutler, M.D., M.P.H., F.R.C.P.C., Department of Medical Oncology, Dana-Farber Cancer Institute; Instructor in Medicine, Harvard University, Boston, MA. Review provided by VeriMed Healthcare Network.
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