Chronic Myelogenous Leukemia (CML)

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Treatment

Treatment is aimed at reducing the growth of the leukemic cells in the bone marrow and may bring about a remission (when no leukemia can be found) with good control of the symptoms of the disease.

The chronic phase can be controlled with chemotherapy, which can be given as an outpatient. Interferon has been used to achieve temporary remission.

The FDA recently approved a new drug for CML called imatineb (Gleevec), which is particularly effective when the disease has not responded to standard treatment (bone marrow transplant). This drug works directly on the leukemic cells to slow their growth. A bone marrow transplant preceded by high-dose chemotherapy and radiation therapy remains the standard treatment, however, although not all people with CML are suitable candidates for transplantation or have a suitable donor.

It is not known at the present time which patients should receive a bone marrow transplant as the first treatment and who should receive Gleevec. Participation in a medical study ("clinical trial") comparing these treatments may be appropriate. Since treatment recommedations for CML are changing quickly with new research findings, you should discuss in detail with your oncologist the advantages and disadvantages of each option.

SELF CARE MEASURES
To minimize bleeding, apply ice and pressure to any external bleeding. A soft toothbrush and electric razor should be used for personal hygiene. An increase in calories and protein in diet may help reduce the side effects associated with chemotherapy. Planning daily activities with scheduled rest periods can help to prevent the fatigue associated with anemia.