Chronic Gouty Arthritis

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Overview, Causes, & Risk Factors

Gout is caused by a defect in metabolism which results in an overproduction of uric acid or leads to reduced ability of the kidney to eliminate uric acid. The exact cause is unknown. Risk is increased in males, postmenopausal women, and people with hypertension. Heavy alcohol use, diabetes, obesity, sickle cell anemia, and kidney disease also increase risk, as does lack of preventative measures in those with prior attacks.

The condition may also develop in people who take drugs which interfere with uric acid excretion.

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