Autosomal Dominant

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Description

The inheritance of genetic diseases, abnormalities, or traits is described by both the type of chromosome on which the abnormal gene resides (autosomal or sex chromosome), and by whether the trait itself is dominant or recessive. This is due to whether a single defective gene from one parent (dominant inheritance) or both copies of the gene (one from each parent) are defective (recessive inheritance).

Autosomal diseases are inherited through the non-sex chromosomes (pairs 1 through 22). Sex-linked diseases are inherited through one of the pairs of sex chromosomes, the X chromosome (diseases are not inherited through the Y chromosome).

Dominant inheritance occurs when an abnormal gene from ONE parent is capable of causing disease even though the matching gene from the other parent is normal. The abnormal gene dominates the outcome of the gene pair.

Recessive inheritance occurs when BOTH genes of a pair must be abnormal to produce disease. If only one gene in the pair is abnormal, the disease does not occur or is only mildly present. However, a person with a single defective gene is called a carrier, meaning the disease can be passed on to children.

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