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You are here : AllRefer.com > Health > Special Topic > Autosomal Dominant: Description

Autosomal Dominant

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Alternate Names : Genetics - Autosomal Dominant, Inheritance - Autosomal Dominant


Definition

A single, abnormal gene on one of the autosomal chromosomes (one of the first 22 "non-sex" chromosomes) from either parent can cause certain diseases. One of the parents will usually have the disease (since it is dominant) in this mode of inheritance. Only one parent must have an abnormal gene in order for the child to inherit the disease.

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Autosomal Dominant Genes
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Description

The inheritance of genetic diseases, abnormalities, or traits is described by both the type of chromosome on which the abnormal gene resides (autosomal or sex chromosome), and by whether the trait itself is dominant or recessive. This is due to whether a single defective gene from one parent (dominant inheritance) or both copies of the gene (one from each parent) are defective (recessive inheritance).

Autosomal diseases are inherited through the non-sex chromosomes (pairs 1 through 22). Sex-linked diseases are inherited through one of the pairs of sex chromosomes, the X chromosome (diseases are not inherited through the Y chromosome).

Dominant inheritance occurs when an abnormal gene from ONE parent is capable of causing disease even though the matching gene from the other parent is normal. The abnormal gene dominates the outcome of the gene pair.

Recessive inheritance occurs when BOTH genes of a pair must be abnormal to produce disease. If only one gene in the pair is abnormal, the disease does not occur or is only mildly present. However, a person with a single defective gene is called a carrier, meaning the disease can be passed on to children.

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Definition
Description
Chances of inheriting a trait
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Topics that might be of interest to you

Other Topics

Autosomal Recessive
Chromosome
Genes
Genetic Counseling and Prenatal Diagnosis
Genetics
Sex-Linked Dominant
Sex-Linked Recessive

Review Date : 7/25/2003
Reviewed By : Douglas R. Stewart, M. D., Division of Medical Genetics, Hospital of the University of Pennsylvania, Philadelphia, PA. Review provided by VeriMed Healthcare Network.

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Page Last Updated: 19 Jul, 2008