Agammaglobulinemia

Pictures & Images

See all Pictures & Images

Overview, Causes, & Risk Factors

Agammaglobulinemia is rare disorder that only affects male as it is inherited as an X-linked recessive trait (like hemophilia). It is the result of a genetic abnormality that blocks normal B-lymphocyte differentiation (development into normal mature cell). As a consequence, the body produces very little (if any) gamma globulin (IgG) and other immunoglobulins in the bloodstream. Immunoglobulins are molecules that play a significant role in the immune response, which protects against illness and infection.

In the absence of protective immunoglobulins, affected individuals develop repeated infections. People with this disorder are particularly susceptible to bacterial infections caused by Hemophilus influenzae, pneumococcus (Streptococcus pneumoniae), and staphylococci as well as repeated viral infections. The upper respiratory tract, lungs, and skin are common sites of infection.

Today's Top News Stories
•	Falls Are Top Cause of Injury, Death Among Elderly - Jul 19, 2008, 09:00 Not all homes are the same, but common sense measures can reduce the risk, expert says.
•	Heart Blood Vessels Grown in the Lab - Jul 18, 2008, 19:00 Could offer a future alternative to bypass surgery, researchers say.
•	Clinical Trials Update: July 18, 2008 - Jul 18, 2008, 09:24 Breast Cancer Hot Flashes Emphysema
•	Loud Music in Bars Hastens Drinking - Jul 18, 2008, 16:00 French researchers say blasting tunes makes patrons down more alcohol in less time.
•	Breast-Fed Babies Have Fewer GI Infections - Jul 18, 2008, 17:00 But they're more likely to be iron-deficient, study finds.