Childhood cerebral type:

• Changes in muscle tone, especially muscle spasms and spasticity
• Crossed eyes (strabismus)
• Decreased understanding of verbal communication (aphasia)
• Deterioration of handwriting
• Difficulty at school
• Difficulty understanding spoken material
• Hearing loss
• Hyperactivity
• Worsening nervous system deterioration
  • Coma
  • Decreased fine motor control
  • Paralysis
• Seizures
• Swallowing difficulties
• Visual impairment or blindness

Adrenomyelopathy:

• Difficulty controlling urination
• Possible worsening muscle weakness or leg stiffness
• Problems with thinking speed and visual memory

Adrenal gland failure (Addison type):

• Coma
• Decreased appetite
• Increased skin color (pigmentation)
• Loss of weight, muscle mass (wasting)
• Muscle weakness
• Vomiting

• Blood levels
• Chromosome study to look for changes (mutations) in the ABCD1 gene
• MRI of the head