Education of mountain travelers before ascent is the key to prevention. Basic principles include: gradual ascent, stopping for a day or two of rest for each 2,000 feet (600 meters) above 8,000 feet (2,400 meters); sleeping at a lower altitude when possible; and learning how to recognize early symptoms so you can return to lower altitude before symptoms get worse.

Mountaineering parties traveling above 9,840 feet (3,000 meters) should carry an oxygen supply sufficient for several days.

Acetazolamide (Diamox) helps speed the process of getting used to higher altitudes, and reduces minor symptoms. This drug should be taken starting one day before the ascent and continue one to two days into the excursion. This is recommended for those making a rapid ascent to high altitudes.

Those who may be prone to anemia (particularly women) should consult a doctor regarding an iron supplement to correct the condition before traveling at high altitudes. People with anemia have a reduced red blood cell count, and therefore a lower amount of oxygen carried in the blood.

Drink enough fluids, avoid alcohol, and eat regularly. Foods should be relatively high in carbohydrates.

People with underlying heart or lung diseases should avoid high altitudes.